| ABSTRACT Objective:To investigate the influence of caudal anesthesia with compound methylene blue and lidocaine on stress index of patients undergone anorectal surgery. Methods:Clinical data of 90 patients undergone anorectal surgery were retrospective analyzed. Those patients were divided into observation group (n=45, received caudal anesthesia with compound methylene blue + lidocaine) and control group (n=45, received caudal anesthesia with lidocaine) according to the anesthetic drugs. The difference of VAS score in two groups was compared at the end of surgery, 3 h, 12 h, 24 h and 48 h after surgery. The levels of serum cortisol (Cor), norepinephrine (NE) and epinephrine (E) were detected in two groups at preoperative, end and 2 d after surgery. The gastrointestinal function recovery and complications were observed in two groups. Results: The VAS scores in observation group were significantly lower than control group at all postoperative time points (P<0.05). Compared with preoperative, the serum Cor, NE and E levels in two groups were significantly increased at end of surgery and 2 d after surgery, while the ascending range of stress indexes in observation group were less than control group (P<0.05). Recovery time of bowel sounds, evacuation time and defecation time in observation group were shorter than control group (P<0.05). The occurrence rate of copracrasia, pain in anus and edema around anus in observation group were significantly lower than control group (P<0.05). Conclusion:Caudal anesthesia with compound methylene blue and lidocaine can effectively reduce postoperation pain of patients undergone anorectal surgery, reduce the stress response, promote postoperative gastrointestinal function recovery and reduce the incidence of complications. |
