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慢性阻塞性肺疾病患者用药依从性的影响因素分析
Analysis of Influencing Factors of Medication Compliance in Patients with Chronic Obstructive Pulmonary Disease
  
DOI:
中文关键词:  慢性阻塞性肺疾病  用药依从性  影响因素
英文关键词:Chronic obstructive pulmonary disease  Medication compliance  Influencing factors
基金项目:国家自然科学基金青年科学基金项目(编号:71704075)
作者单位
沈俊 吴秋惠 陈燕华 葛卫红 南京鼓楼医院药学部 南京 210008 
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中文摘要:
      摘 要 目的:评估慢性阻塞性肺疾病(COPD)患者的用药依从性,并找出与依从性有关的因素,实现患者的有效管理。方法:选取2017年6~12月在我院呼吸内科门诊就诊的COPD稳定期并接受药物治疗的患者作为研究对象。登记患者一般信息,在3个月后电话随访患者,采用COPD患者自我评估测试问卷(CAT)评分和药物依从性问卷(MAQ)评分评估健康状况和用药依从性,采用χ2检验与多因素 Logistic 回归分析以确定依从性差的影响因素。结果:147例患者参与了研究,用药依从性差的患者比例为58.5%。患者的年龄、医疗费用支付方式、吸烟与否、独居与否、合并用药数量的不同对用药依从性的影响有统计学意义(P<0.05),患者性别、文化程度、疾病持续时间、CAT评分的不同对用药依从性的影响无统计学意义(P>0.05)。结论:中年、独居、吸烟、自费、合并多种用药患者的用药依从性应被特别注意。对于中年和独居患者,每日一次向其短信提醒规律用药,合并多种用药的患者应使用低给药频率的药物,国家应进一步完善医疗保险制度,都有助于促进用药依从性的改善。
英文摘要:
      ABSTRACT Objective: To evaluate medication compliance in patients with chronic obstructive pulmonary disease (COPD) and identify factors related to compliance to achieve effective management of patients. Methods:From June 2017 to December 2017, patients with stable COPD and receiving drug treatment in the outpatient department of respiratory of our hospital were selected as the research objects. Patients were enrolled in general information and followed up by telephone three months later. COPD assessment test (CAT) score and medication adherence questionnaire (MAQ) score were used to evaluate health status and medication compliance. Chi square test and multivariate Logistic regression analysis were used to determine the influencing factors of noncompliance. Results: 147 patients participated in the study, and the proportion of patients with low compliance was 58.5%. The medication compliance was associated with age, mode of payment for medical expenses, smoking, living alone or not, and the number of drugs used in combination (P<0.05), was not related to gender, education level, duration of disease, and CAT score (P>0.05). Conclusion:Medication compliance of middle age, living alone, smoking, self pay, combined with a variety of drugs should be paid special attention to patients. For middle aged and solitary patients, daily text messages remind them of regular drug use, and patients with multiple drugs should use drugs with low frequency of administration, the government should further improve the medical insurance system, all of these contribute to improved medication compliance.
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