| ABSTRACT Objective:To investigate the general clinical characteristics and possible mechanisms of moxifloxacin induced thrombocytopenia, and to provide references for rational drug use in clinical practice. Methods:Literatures of thrombocytopenia induced by moxifloxacin were searched from domestic and foreign literature databases until February 2019. After screening, data from included literature were extracted and analyzed, including patient basic data, medication data, combination drugs, occurrence time, clinical manifestations, treatment method and outcome. Results: A total of 9 cases were extracted. Among them, 5 cases were male and 4 was female, the average age was (57.7±13.1) years old. 6 patients had ADR within 10 days after administering moxifloxacin. The lowest count of platelet decreased to 30×109·L-1 in 8 cases, and 5 of them were under 10×109·L-1. All patients suffered from thrombocytopenia caused by moxifloxacin and 8 patients developed serious ADR, at last they all recovered after treatment. Conclusion:Moxifloxacin induced thrombocytopenia is rare while may develop serious consequence. Great importance should be attached to the ADR. |
