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| 不同用法用量氨甲环酸防治老年人髋关节置换术中出血观察 |
| Efficacy and Safety of Different Dosages and Usages of Tranexamic Acid in Reducing Blood Loss in Elderly Patients Undergoing Hip Arthroplasty |
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| DOI： |
| 中文关键词: 氨甲环酸，老年患者，髋关节置换术，失血量 |
| 英文关键词:Tranexamic acid Elderly patients Hip arthroplasty Blood loss |
| 基金项目:苏州市2016年度产业技术创新专项（编号：SYSD2016156） |
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| 中文摘要: |
| 摘 要 目的：观察不同用法用量氨甲环酸防治老年人髋关节置换术中出血的有效性与安全性。 方法：100例行髋关节置换术的老年患者随机分配至4个组。静脉滴注组术前10 min静脉滴注氨甲环酸1 g；关节腔注射组术中关节腔注射氨甲环酸2 g；静脉联合关节腔组术前10 min静脉滴注氨甲环酸1 g，并于术中关节腔注射氨甲环酸2 g；对照组术前及术中不使用任何止血药物。比较4组患者术中出血量、术后引流量、凝血功能变化、住院时间、治愈率、28 d生存率、不良反应发生率等指标。 结果：静脉联合关节腔注射组与对照组术后引流量的差异有统计学意义，静脉组与对照组理论总失血量的差异有统计学意义，其他各组间出血量或引流量差异无统计学意义。各组纵向比较，术前和术后各凝血功能指标差异部分有统计学意义，术后普遍存在凝血功能障碍。各组间住院时间、治愈率、28天生存率、不良反应发生率差异无统计学意义。 结论：氨甲环酸在老年人髋关节置换术中有较好的止血有效性和安全性，在疗效相近的情况下，建议使用单静脉滴注。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the efficacy and safety of different dosages and usages of tranexamic acid in reducing blood loss in elderly patients undergoing hip arthroplasty. 〖WTHZ〗Methods:〖WTBZ〗A prospective study was performed to screen 100 elderly patients undergoing hip arthroplasty, who were divided into 4 groups. The differences in intraoperative blood loss and postoperative drainag, changes in coagulation function, adverse reactions, hospitalization time and clinical outcomes were compared between different tranexamic acid dosage groups. 〖WTHZ〗Results:〖WTBZ〗There was a statistically significant difference in the postoperative drainage between the venous + joint cavity group and the statistical group, and in the total blood loss between the venous group and the control group. Surgery caused a coagulopathy, but there was no significant difference in hospitalization time, cure rate, 28 day survival rate, and incidence of adverse reactions between any two groups. 〖WTHZ〗Conclusion:〖WTBZ〗Tranexamic acid has good hemostatic efficacy and safety elderly patients undergoing hip arthroplasty. Under the premise of similar efficacy, single intravenous infusion should be recommended. |
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