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脾氨肽联合沙美特罗替卡松治疗小儿支气管哮喘疗效及对患儿免疫功能影响观察
Effects of Spleen Aminopeptide Combined with Salmeterol Fluticasone on the Lung Function and Immune Function in Children with Bronchial Asthma
  
DOI:
中文关键词:  脾氨肽  沙美特罗替卡松  小儿支气管哮喘  肺功能  免疫功能
英文关键词:Spleen aminopeptide  Salmeterol fluticasone  Bronchial asthma in children  Lung function  Immune function
基金项目:国家卫生计生委医药卫生科技发展研究项目(编号:W2015EAE039)
作者单位
付小丽 吕建飞 何春风 丽水市人民医院儿科 浙江丽水 323000 
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中文摘要:
      摘 要 目的:探讨脾氨肽联合沙美特罗替卡松治疗小儿支气管哮喘的疗效,及对患儿免疫功能的影响。 方法:102例小儿支气管哮喘患者随机分为观察组和对照组,每组51例。两组患者都接受止咳化痰等对症治疗,对照组在此基础上给予沙美特罗替卡松气雾剂治疗,观察组在对照组基础上再加用脾氨肽口服冻干粉治疗,两组患儿均连续治疗2周。比较两组患儿的治疗效果和临床症状消失时间,观察两组患儿治疗前后肺功能及血清细胞免疫水平变化。结果:观察组患儿的咳嗽、哮鸣音及憋喘消失时间均短于对照组(P<0.05);治疗总有效率显著高于对照组(P<0.05)。两组患儿FVC、FEV1、FEV1/FVC等肺功能指标,T细胞亚群及IgE水平均较治疗前显著改善(P<0.05),且观察组上述指标均明显优于对照组(P<0.05)。结论:脾氨肽联合沙美特罗替卡松可迅速改善小儿支气管哮喘患儿的临床症状,提升肺功能,临床效果较好,其作用机制可能与提高患儿的免疫功能有关。
英文摘要:
      ABSTRACT Objective:To investigate the efficacy of using spleen aminopeptide combined with salmeterol fluticasone in the treatment of bronchial asthma children and its effect on immune function. Methods:102 children with bronchial asthma were randomly divided into the observation group and the control group (51 cases in each group). Both groups received symptomatic treatments such as cough and phlegm, and the control group were given salmeterol fluticasone aerosol treatment, while the observation group were treated with spleen aminopeptide orally lyophilized powder on the basis of the control group. All patients were treated continuously for 2 weeks. The therapeutic effects and disappearance time of clinical symptoms were recorded and compared between the two groups, as well as lung function and serum cellular immunity changes before and after treatment. Results: The disappearance time of cough and wheezing in the observation group was shorter than that in the control group (P<0.05). The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). The lung function indexes, T cell subsets and IgE levels in the two groups were significantly improved compared with those before treatment (P<0.05). And the above indexes in the observation group were significantly better than those in the control group (P<0.05). Conclusion:Spleen aminopeptide combined with salmeterol fluticasone can be used to improve the clinical symptoms and lung functions in children with bronchial asthma, which clinical mechanism may be related to the improvement of the immune functions.
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